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The Association of Pro-inflammatory Cytokines as a Significant Predictors of Knee Osteoarthritis Pathogenesis

Osteoarthritis (OA) is a progressive degenerative disorder characterized by chronic joint pain, structural deterioration and functional impairment and affecting of daily living. Increasing evidence suggests that inflamm…

The key role of vitamin E supplementation on secondary Iron overload and the oxidative hassle in transfusion dependant beta thalassemia major children

Children with β- thalassemia major experience significant cellular oxidative injury predominantly due to excessive breakdown of uncoupled globin chain and secondary iron overload. These processes contribute to cellular…

CORRELATION OF HYOID BONE MORPHOLOGY WITH AGE AND SEX IN FORENSIC IDENTIFICATION

The hyoid bone, a solitary U-shaped skeletal feature located in the anterior neck, has increasingly being studied for its forensic value in detecting sex and age. Variations in its morphometric properties and fusion pat…

ETIOLOGICAL SPECTRUM AND CLINICAL PROFILE OF PANCYTOPENIA IN ADULTS: A PROSPECTIVE STUDY AT A TERTIARY CARE HOSPITAL

Pancytopenia is a haematological condition, characterized by a simultaneous reduction of erythrocytes, leukocytes, and platelets in the peripheral circulation. It manifests a wide spectrum of primary disorders, includin…

EVALUTION OF PATIENTS ON CHRONIC LITHIUM TREATMENT: A CROSS SECTIONEAL STUDY

Lithium remains an essential component of long-term treatment maintenance of the bipolar disorder; however, it is associated with possible endocrine, renal and cardiac adverse events that require close monitoring. The c…

Surgical Treatment Functional Outcome of Delayed Clubfoot in Tibebe Gihon Specialized Hospital from June 2022- June 2023: Case Series Study

Idiopathic clubfoot occurs in approximately 1 in 1,000 live births, with most cases (80-91%) found in low-and middle-income countries (LMICs). Due to limited access to early treatment, many children present with delayed…

Effect of Blended Fertilizers on Yield Performance of Potato (Solanum tuberosum L.)Varieties and Soil Physicochemical Properties in Angacha District, Southern Ethiopia

Soil fertility depletion constrains potato productivity in Southern Ethiopia, where smallholder farmers rarely apply optimal nutrient management or improved varieties. This study evaluated the effects of blended fertili…

Measuring Smart Sports Facility Dimensions for Smart Cities: Scale Development and Validation Using Mixed Methods, EFA and PLS-CFA

Smart sports facilities are increasingly positioned as key urban assets within smart-city agendas, yet there is no widely accepted, empirically validated instrument for benchmarking facility-level "smartness". This stud…

ASSESSMENT OF MITOCHONDRIAL DNA CONTENT AND OXIDATIVE STRESS BIOMARKERS IN CUTANEOUS LICHEN PLANUS {Retracted article }

RETRACTED ARTICLE

EFFECT OF THREE MONTHS COURSE OF DAILY TERIPARATIDE INJECTION ON OSTEOPOROSIS IN A RURAL POPULATION: A ONE YEAR FOLLOW UP STUDY USING pDEXA

Osteoporosis continues to represent a significant public-health problem, especially in the rural setting, where access to the availability of sophisticated diagnosis and treatment options limited. Awareness, knowledge a…

PREVALENCE OF STRESS AND ITS CORRELATION WITH COGNITION AMONG MEDICAL STUDENTS

Stress is highly prevalent among medical students due to academic demands, clinical responsibilities, and psychosocial factors. Persistent stress has been linked to impaired cognitive performance and long-term neuropsyc…

IMPACT OF AN INTEGRATED QUIZ-BASED LEARNING APPROACH ON ACADEMIC PERFORMANCE AND STUDENT PERCEPTION IN FIRST-YEAR MBBS STUDENTS

Teacher - centered approach in medical education are now a day's being replaced by integrated, learner centered ones. Using quiz based learning, especially across curriculum areas, facilitates deeper understanding, acqu…

MATERNAL MORTALITY IN A TERTIARY CARE HOSPITAL: A 3-YEAR REVIEW

Motherhood is associated with multiple health risks, including maternal mortality remaining a major global public health concern, particularly in Empowered Action Group states of India, which continue to report higher l…

Perceptions of Family Planning Integration across Health Service Units among WomenAttending Antenatal Care in Gurage Zones, Ethiopia

Unintended pregnancy is a significant public health concern, particularly in Sub-Saharan African countries. Notably, positive perception towards family planning integration among women is impactful in decreasing materna…

Mapping Enset Value Chain: Roles, Constraints, and Opportunities in Guraghe Zone, Ethiopia

Enset is a staple food crop consumed primarily by many people in the Guraghe Zone. This study aims to examine the Enset value chain in the Guraghe Zone, focusing on the roles, constraints, and opportunities faced by the…

Oxidative Puzzle of Female Infertility: A Systematic Narrative Review

Oxidative stress, characterized by an imbalance between the production of the reactive oxygen species (ROS) and the ability of the antioxidant defense systems. It is crucial to the pathophysiology of infertile women, de…

GIS and SWAT Model-Based Assessment of Theoretical Hydropower Potential in the Furfuro Watershed, Ethiopia

Ethiopia possesses abundant water resources and favorable topography for hydropower development; however, comprehensive data on many perennial rivers and their hydropower potential remain scarce. Accurate information is…

Change in Spinopelvic Parameters Before and After Lumbar Disc Herniation Surgery

Background: Sagittal balance depends on the interaction between lumbar alignment and spinopelvic parameters such as lumbar lordosis (LL), pelvic tilt (PT), sacral slope (SS), and pelvic incidence (PI). Although these pa…

Computer-aided Discovery of Novel COX-2 Inhibitors for Anti-inflammatory Therapy Using Pharmacophore Modelling, Molecular Docking, ADMET, and Virtual Screening

Cyclooxygenase-2 (COX-2) is a central enzyme in inflammation and a validated target for anti-inflammatory drug development. However, many existing COX-2 inhibitors cause gastrointestinal and cardiovascular side effects,…

Cortisol Signaling in Stress-Induced Pathophysiology: Molecular Mechanism and Therapeutic Implication

Cortisol is a glucocorticoid hormone essential for the physiological stress response. Its secretion is controlled by the hypothalamic-pituitary-adrenal (HPA) axis, which coordinates the body's adaptive behaviour to inte…

Gene Therapy Approaches in Hematological Malignancies: Current Strategies and Future Directions

Hematological malignancies, such as leukemia, lymphoma, and myeloma, are cancers originating in the bone marrow and lymphatic system, marked by the uncontrolled growth of blood cells. Gene therapy offers a revolutionary…

Sleep Quality in Hemodialysis Patients According to Renal Anemia Treatment Outcomes

Backgound: We assessed the impact of renal anemia treatment on sleep quality among hemodialysis (HD) patients. Methods: To be included in the study, patients had to have received epoetin (EPO) therapy within the past ye…

Late Management of An Atrial Septal Defect Closure Device Embolized to Left Ventricle Outflow Tract

Atrial septal defect (ASD) which is among most common congenital heart disease diagnosed in adults. It is commonly managed with percutaneous closure successfully. However, percutaneous closure procedure has been associa…

Evaluation of the Relationship Between Vitamin D and Inflammation in Type 2 Diabetes and Diabetic Complications

Type 2 diabetes mellitus (T2DM) and its microvascular complications are characterized by chronic inflammation, which arises as a consequence of persistent hyperglycemia and insulin resistance. In obese patients with T2D…

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