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APACHE II, APACHE III AND SOFA SCORES AS PREDICTORS OF MORTALITY IN ACUTE RESPIRATORY DISTRESS SYNDROME: A COMPARATIVE PROSPECTIVE STUDY WITH ROC ANALYSIS

Hakim Baset, K, Harika, Mithun N. Kagalkar · International Journal of Clinical and Biomedical Research;

Background: APACHE II, APACHE III and SOFA are widely used intensive care severity scores, but their comparative discrimination for mortality in acute respiratory distress syndrome (ARDS) is not well established in Indi…

ALTERATION OF COAGULATION PROFILE AS A PREDICTOR OF BLEEDING AND MORTALITY IN PATIENTS WITH LEPTOSPIROSIS: A PROSPECTIVE OBSERVATIONAL STUDY

Mithun N. Kagalkar, Harika K, Hakim Baset · International Journal of Clinical and Biomedical Research;

Background: Bleeding is a recognised complication of severe leptospirosis, but data correlating coagulation parameters with bleeding and outcome remain limited from Indian centres. Methods: In this prospective, single-c…

AETIOLOGY, CLINICAL PROFILE AND DEMOGRAPHIC DETERMINANTS OF SEVERITY AND OUTCOME IN ACUTE RESPIRATORY DISTRESS SYNDROME: A PROSPECTIVE OBSERVATIONAL STUDY FROM A MEDICAL ICU

Hakim Baset, Mithun N. Kagalkar, K, Harika · International Journal of Clinical and Biomedical Research;

Background: Acute respiratory distress syndrome (ARDS) has diverse aetiologies and a variable course. Indian intensive care unit (ICU) data on how demographic factors, mode of admission and aetiology relate to Berlin se…

COMORBIDITIES AND ADDICTIONS AS PREDICTORS OF SEVERITY AND OUTCOME IN ACUTE RESPIRATORY DISTRESS SYNDROME: A PROSPECTIVE OBSERVATIONAL STUDY

Hakim Baset, Mithun N. Kagalkar, K, Harika · International Journal of Clinical and Biomedical Research;

Background: Pre-existing comorbidities and addictions are common in critically ill patients, but their contribution to severity and mortality once acute respiratory distress syndrome (ARDS) is established is incompletel…

CLINICAL, HAEMATOLOGICAL, BIOCHEMICAL AND ARTERIAL BLOOD GAS PARAMETERS AS PREDICTORS OF SEVERITY AND OUTCOME IN ACUTE RESPIRATORY DISTRESS SYNDROME

Hakim Baset, Mithun N. Kagalkar, K, Harika · International Journal of Clinical and Biomedical Research;

Background: Bedside vital signs and routine laboratory tests are available within minutes of intensive care unit (ICU) admission, but their comparative value in tracking severity and mortality in acute respiratory distr…

INTERVENTIONS, COMPLICATIONS AND ICU COURSE AS PREDICTORS OF OUTCOME IN ACUTE RESPIRATORY DISTRESS SYNDROME: A PROSPECTIVE OBSERVATIONAL STUDY

Hakim Baset, K, Harika, Mithun N. Kagalkar · International Journal of Clinical and Biomedical Research;

Background: Patients with acute respiratory distress syndrome (ARDS) frequently require organ support and develop intensive care unit (ICU)-acquired complications. How these relate to severity and mortality is less well…

CLINICO-EPIDEMIOLOGICAL PROFILE, COMORBIDITIES AND CO-INFECTIONS AS DETERMINANTS OF OUTCOME IN LEPTOSPIROSIS: A PROSPECTIVE OBSERVATIONAL STUDY

Mithun N. Kagalkar, Arvind M N, K, Harika · International Journal of Clinical and Biomedical Research;

Background: Leptospirosis is an underreported zoonosis with a broad clinical spectrum. Indian data on how comorbidity and co-infection relate to outcome remain limited. Methods: In this prospective, single-centre observ…

ORGAN-SYSTEM COMPLICATIONS AND THEIR ASSOCIATION WITH MORTALITY IN SEVERE LEPTOSPIROSIS: A PROSPECTIVE OBSERVATIONAL STUDY

K, Harika, Mithun N. Kagalkar, Radha A · International Journal of Clinical and Biomedical Research;

Background: Severe leptospirosis involves multiple organ systems, and the relative contribution of each to mortality is not well quantified in Indian cohorts. Methods: In this prospective, single-centre observational st…

WEIL'S SYNDROME AND CLINICAL OUTCOME IN LEPTOSPIROSIS: A PROSPECTIVE OBSERVATIONAL STUDY

Mithun N. Kagalkar, K, Harika, Radha A · International Journal of Clinical and Biomedical Research;

Background: Weil's syndrome - the combination of jaundice, renal dysfunction and haemorrhagic diathesis - represents the most severe phenotype of leptospirosis, but its incidence and outcome relative to non-icteric dise…

INITIAL SYMPTOMATOLOGY AS A PREDICTOR OF CLINICAL OUTCOME IN LEPTOSPIROSIS: A PROSPECTIVE OBSERVATIONAL STUDY

K, Harika, Radha A, Mithun N. Kagalkar · International Journal of Clinical and Biomedical Research;

Background: Leptospirosis presents with a wide, non-specific symptom spectrum that delays diagnosis. Identifying which presenting features carry prognostic weight could support earlier triage. Methods: In this prospecti…

COMPARATIVE HISTOLOGICAL STUDY ON THE SPLEEN OF HUMAN, GOAT, DOG, RABBIT AND PIG

Ashwin Kumar, Bhaskar B. Reddy, Chandraprabha Choudhary, Meghana Mishra, Arjun Singh Parmar · International Journal of Clinical and Biomedical Research;

Background: The spleen is the largest secondary lymphoid organ and contributes to immune defence, blood filtration, clearance of senescent erythrocytes, iron recycling, and haematological regulation. Its microarchitectu…

CLONIDINE VERSUS DEXAMETHASONE AS AN ADJUVANT TO 0.25% BUPIVACAINE FOR WOUND INFILTRATION ANALGESIA AFTER ELECTIVE CAESAREAN SECTION

Geetha M, Lokesh S B, Sumanth S, Balaji Nallathambi · International Journal of Clinical and Biomedical Research;

Background: Pain after caesarean section interferes with early ambulation, maternal comfort and the establishment of breastfeeding. Wound infiltration with local anaesthetic is a simple, inexpensive adjunct to multimoda…

REDUCED SERUM AND URINARY FLUORIDE IN DIABETIC NEPHROPATHY: RELATIONSHIP WITH RENAL DYSFUNCTION AND OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS

Yadav, Bhuneshwar, Joshi , Prangyada Reecha, Verma, Kshitij, K N, Shashidhar · International Journal of Clinical and Biomedical Research;

Background: Type 2 Diabetes Mellitus (T2DM) is a major cause of diabetic nephropathy (DN) and progressive renal dysfunction. Impaired kidney function may result in fluoride retention, which, together with hyperglycemia-…

PATIENT PREFERENCES AND UTILIZATION PATTERNS FOR GENERIC VERSUS BRANDED MEDICINES: AN OBSERVATIONAL CROSS-SECTIONAL ANALYSIS

Lagishetty Radhakrishna, Shaik Muddasirun, K. V. R. Barath Raju · International Journal of Clinical and Biomedical Research;

Generic medicines are central to containing healthcare costs and improving access to essential treatment. Despite sustainedgovernment initiatives promoting their use in India, the acceptance and utilization of generic m…

INTEGRATIVE ASSESSMENT OF PHENOTYPIC AND MOLECULAR APPROACHES FOR EVALUATING BIOFILM FORMATION IN CLINICAL ISOLATES OF COAGULASE-NEGATIVE STAPHYLOCOCCI

Vanaparthi, Nagarajuu, Sadawarte, Kalpana · International Journal of Clinical and Biomedical Research;

Several bacterial species once dismissed as harmless commensals are increasingly implicated in human infection. Coagulase-negative staphylococci (CoNS) are a prominent example, causing a broad spectrum of disease in hos…

POSTOPERATIVE WOUND INFECTIONS WITH SPECIAL REFERENCE TO METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS: A THREE-YEAR EXPERIENCE AT MULTICENTRE TERTIARY CARE TEACHING HOSPITALS IN SOUTH INDIA

Vanaparthi, Nagarajuu, Mudu, Venkateswarlu, P, Vimala · International Journal of Clinical and Biomedical Research;

Infections are among the most common adverse events affecting patient safety. Among the various healthcare-associated infections (HAI), surgical site infection (SSI) is a serious postoperative complication occurring in…

HAND GRIP STRENGTH IN RELATION TO THE SIX-MINUTE WALK TEST AMONG PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

S, Praveen Kumar, B, Jayaprakash · International Journal of Clinical and Biomedical Research;

Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation, diminished exercise tolerance, and skeletal muscle dysfunction. Objective assessment of functional exercise capacity is ce…

COMPARATIVE EVALUATION OF PERIPHERAL BLOOD SMEAR AND IMMUNOCHROMATOGRAPHIC TEST FOR MALARIA DIAGNOSIS IN A RURAL TERTIARY CARE HOSPITAL

Patel, Anishka, R, Sinha, SB, Roushani, DS, Bhalerao, Vaidya, SM, Jain · International Journal of Clinical and Biomedical Research;

Background: Malaria remains a major public health concern in India, particularly in rural settings, where accurate and rapid diagnosis is crucial for effective management. Although peripheral blood smear (PBS) examinati…

SERUM URIC ACID LEVELS IN ESSENTIAL HYPERTENSION AND THEIR ASSOCIATION WITH THE SEVERITY AND DURATION OF DISEASE

Mahajan, Rahul, Kaur, Navpreet · International Journal of Clinical and Biomedical Research;

Hypertension is a leading cause of cardiovascular and renal morbidity and mortality. Emerging evidence suggests thatserum uric acid (SUA) may contribute to the pathogenesis of essential hypertension through endothelial…

USE OF INOTROPIC AGENTS IN VARIOUS MEDICAL EMERGENCIES: A PROSPECTIVE OBSERVATIONAL STUDY

Bhuriya, Taruna, Ghodke, Rajashree, Kunkulol, Rahul · International Journal of Clinical and Biomedical Research;

Inotropes and vasopressors are central to the management of critically ill patients with haemodynamic instability. Their use varies widely across intensive care units (ICUs), and standardised prescribing patterns remain…

KNOWLEDGE OF RABIES AND POST-EXPOSURE PROPHYLAXIS AMONG PATIENTS ATTENDING THE OUTPATIENT DEPARTMENT OF A RURAL PRIMARY HEALTH CENTRE IN TIRUNELVELI: A CROSS-SECTIONAL STUDY

M, Thilagar, N, Rama Swathika, A, Shameema Rubaiya · International Journal of Clinical and Biomedical Research;

Background: Rabies is an almost universally fatal zoonotic encephalitis that continues to pose a significant public health challenge in rural India. Despite the availability of effective post-exposure prophylaxis (PEP),…

EFFICACY OF LOW DOSE ORAL MINOXIDIL (1.25 MG) AS MONOTHERAPY IN MALE ANDROGENETIC ALOPECIA

Mundhada, Krishnakant Girish, Agrawal, Sanjay Nathmal, Mundhada, Ganesh Ranchoddas, Khatri, Hitesh Sureshkumar · International Journal of Clinical and Biomedical Research;

Androgenetic alopecia (AGA) is the most prevalent form of progressive hair loss in men, characterised by androgen-mediated follicular miniaturisation and significant psychosocial impact. Topical minoxidil, the establish…

HPV VACCINE AWARENESS AND FACTORS ASSOCIATED WITH NON-ACCEPTANCE OF HPV VACCINATION AMONG SCHOOL GOING ADOLESCENT GIRLS IN AN URBAN AREA

Manpreet Sodhi, Kaur, Amandeep, Jasleen Kaur · International Journal of Clinical and Biomedical Research;

Cervical cancer is the fourth most common cancer among women worldwide and the second most common cancer among women in India. In 2020, an estimated 123,907 new cases of cervical cancer were diagnosed and 77,348 deaths…

ENHANCING TREATMENT OUTCOMES IN ANDROGENETIC ALOPECIA: A PROSPECTIVE COMPARATIVE EVALUATION OF PLATELET-RICH PLASMA AND MINOXIDIL THERAPY

M G, Madhukumar, Suwarna · International Journal of Clinical and Biomedical Research;

Androgenetic alopecia (AGA) is the most common form of progressive hair loss in adult men. Topical minoxidil is an established first-line therapy, but its onset is slow and adherence to long-term application is variable…

ASSESSMENT OF PHYSICOCHEMICAL AND MICROBIAL DETERMINANTS OF GROUNDWATER QUALITY AND IDENTIFICATION OF EMERGING CONTAMINANT RISK CLUSTERS

Syed Shafi Ahmed, Swati Yadav, Arun Kumar Yadav, Arshiya Masood Siddiqui · International Journal of Clinical and Biomedical Research;

Groundwater is the principal source of drinking water for the majority of India's population, but progressive deterioration of its physicochemical and microbiological quality poses an escalating public health risk. Mult…