Scholarly Article
NADPH Oxidase-Driven Oxidative Stress and an Interplay of SOD and Vitamin C in Chronic Bronchitis.
Raut, Anita
2026-03-27 · International Journal of Clinical and Biomedical Research · Sumathi Publications
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a progressive condition characterized by irreversible airflow limitation and an abnormal inflammatory response in the lungs. Extracellular superoxide dismutase (EC-SOD) is an antioxidant and anti-inflammatory enzyme highly concentrated in lung tissue and lining fluids. COPD progression is believed to be driven by the release of free radicals and redox-sensitive proteases, leading to small airway inflammation, fibrosis, and alveolar wall destruction. EC-SOD plays a critical role in scavenging free radicals and modulating inflammation associated with COPD. In this study, we investigated the role of EC-SOD in 100 healthy controls and 60 lung disease patients with COPD . Baseline clinical and biochemical parameters were assessed. The results showed a significant increase in malondialdehyde (MDA) levels (p < 0.001) and a significant decrease in superoxide dismutase (SOD) and vitamin E levels (p < 0.001) in COPD patients compared to healthy controls. These findings suggest that reduced antioxidant defenses, particularly lower levels of SOD and vitamin E, contribute to increased oxidative stress, which may play a key role in the pathogenesis and progression of COPD.
Keywords
Oxidative stress, Chronic bronchitis, Vitamin C, NADPH oxidase, Superoxide dismutase
Citation Details
International Journal of Clinical and Biomedical Research, Vol. 11, No. 1, pp. 57-60